Hydrochloric Acid → HCID 67260206, compound

HRID 2175080Notes

Reaction equation

C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([C:20]3[CH:29]=[CH:28][C:27]4[C:26]([CH3:31])([CH3:30])[CH2:25][CH2:24][C:23]([CH3:33])([CH3:32])[C:22]=4[CH:21]=3)[N:15]=2)[CH2:10][CH2:9]1)(C)(C)C.Cl>>[CH3:30][C:26]1([CH3:31])[CH2:25][CH2:24][C:23]([CH3:32])([CH3:33])[C:22]2[CH:21]=[C:20]([C:16]3[N:15]=[C:14]([N:11]4[CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9][CH2:10]4)[CH:19]=[CH:18][N:17]=3)[CH:29]=[CH:28][C:27]1=2

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 68380504HCID 68380504, compound

Product 1

HCID 67260206HCID 67260206, compound

Procedure

The above compound is prepared analogously to FS201 starting {1-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyrimidin-4-yl]piperidin-4-yl}carbamic acid tert-butyl ester. The product is in the form of the hydrochloride.

Workup

customThe above compound is prepared analogously to FS201

Sources & evidence

ORD record: ord-27896045ee4e4823a23bb3c7f3a05e57
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09062015B2

Reaction notes

Loading…