HCID 67607456, compound → HCID 68331159, compound

HRID 2175086Notes

Reaction equation

HRID 2175086 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]3[CH:29]=[CH:28][C:27]4[C:26]([CH3:31])([CH3:30])[CH2:25][CH2:24][C:23]([CH3:33])([CH3:32])[C:22]=4[CH:21]=3)[N:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]3[CH:29]=[CH:28][C:27]4[C:26]([CH3:31])([CH3:30])[CH2:25][CH2:24][C:23]([CH3:33])([CH3:32])[C:22]=4[CH:21]=3)[N:15]=2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 67607456HCID 67607456, compound

Product 1

HCID 68331159HCID 68331159, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

52 mg (0.11 mmol) of 6-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-3′,6′-dihydro-2′H-2,4′-bipyridinyl-1′-carboxylic acid tert-butyl ester are dissolved in 20 ml of ethanol and hydrogenated using a Pd/C cartridge (10%, 30×4 mm) in an H Cube (Thales Nanotechnology). The solvent is subsequently distilled off.

Workup

  1. distillationThe solvent is subsequently distilled off

Sources & evidence

ORD record
ord-f3a66f3ea8934bd099bfe5c19b14331d
Source dataset
uspto-grants-2015_06
Patent number
US09062015B2

Reaction notes

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