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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2175092Generated: October 31, 2026

Hydrochloric Acid → HCID 53250561, compound

https://huagongshe.com/reaction/2175092

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)boronic acidHCID 10353857—
Reactanttert-Butyl [1-(6-bromopyridin-2-yl)piperidin-4-yl]carbamateHCID 45786979—
ProductHCID 53250561HCID 53250561—

Reaction Steps

The preparation is carried out analogously to FS 102 starting from (6′-bromo-3,4,5,6-tetrahydro-2H-1,2′-bipyridinyl-4-yl)carbamic acid tert-butyl ester (preparation analogous to WO2005/26149) and 5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ylboronic acid. The protecting group is subsequently cleaved off in a corresponding manner to FS201. The product is in the form of the hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09062015B2
Source datasetuspto-grants-2015_06
ORD IDord-f2cc81fa2536417d9ece20410ca710c7
Source noteuspto-grants-2015_06