Hydrochloric Acid → HCID 53250561, compound

HRID 2175092Notes

Reaction equation

HRID 2175092 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16](Br)[N:15]=2)[CH2:10][CH2:9]1)(C)(C)C.[CH3:22][C:23]1([CH3:38])[CH2:32][CH2:31][C:30]([CH3:34])([CH3:33])[C:29]2[CH:28]=[C:27](B(O)O)[CH:26]=[CH:25][C:24]1=2.Cl>>[CH3:33][C:30]1([CH3:34])[CH2:31][CH2:32][C:23]([CH3:38])([CH3:22])[C:24]2[CH:25]=[C:26]([C:16]3[N:15]=[C:14]([N:11]4[CH2:10][CH2:9][CH:8]([NH2:7])[CH2:13][CH2:12]4)[CH:19]=[CH:18][CH:17]=3)[CH:27]=[CH:28][C:29]1=2

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 10353857(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)boronic acidHCID 45786979tert-Butyl [1-(6-bromopyridin-2-yl)piperidin-4-yl]carbamate

Product 1

HCID 53250561HCID 53250561, compound

Procedure

The preparation is carried out analogously to FS 102 starting from (6′-bromo-3,4,5,6-tetrahydro-2H-1,2′-bipyridinyl-4-yl)carbamic acid tert-butyl ester (preparation analogous to WO2005/26149) and 5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ylboronic acid. The protecting group is subsequently cleaved off in a corresponding manner to FS201. The product is in the form of the hydrochloride.

Sources & evidence

ORD record
ord-f2cc81fa2536417d9ece20410ca710c7
Source dataset
uspto-grants-2015_06
Patent number
US09062015B2

Reaction notes

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