Hydrochloric Acid → (R)-4-[6'-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-3,4,5,6-tetrahydro-2H-1,2'-bipyridinyl-4-ylamino]butane-1,2-diol

HRID 2175102Notes

Reaction equation

HRID 2175102 reaction equation
[NH2:1][CH2:2][CH2:3][C@@H:4]([OH:7])[CH2:5][OH:6].[CH3:8][C:9]1([CH3:34])[CH2:18][CH2:17][C:16]([CH3:20])([CH3:19])[C:15]2[CH:14]=[C:13]([CH:21]3[N:26](C4C=CC=CN=4)[CH2:25][CH2:24][C:23](=O)[CH2:22]3)[CH:12]=[CH:11][C:10]1=2.Cl>>[CH3:8][C:9]1([CH3:34])[CH2:18][CH2:17][C:16]([CH3:20])([CH3:19])[C:15]2[CH:14]=[C:13]([C:21]3[N:26]=[C:25]([N:26]4[CH2:21][CH2:22][CH:23]([NH:1][CH2:2][CH2:3][C@@H:4]([OH:7])[CH2:5][OH:6])[CH2:24][CH2:25]4)[CH:24]=[CH:23][CH:22]=3)[CH:12]=[CH:11][C:10]1=2

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 683809126-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-2,3,5,6-tetrahydro-1,2'-bipyridinyl-4-oneHCID 86671780(R)-4-aminobutane-1,2-diol

Product 1

HCID 68331039(R)-4-[6'-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-3,4,5,6-tetrahydro-2H-1,2'-bipyridinyl-4-ylamino]butane-1,2-diol

Procedure

The preparation is carried out analogously to FS1008 starting from 21 mg (0.199 mmol) of (R)-4-aminobutane-1,2-diol and 80 mg (0.199 mmol) of 6-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-2,3,5,6-tetrahydro-1,2′-bipyridinyl-4-one. The product is in the form of the hydrochloride.

Sources & evidence

ORD record
ord-d43d3e5035854520ac59eac8479db526
Source dataset
uspto-grants-2015_06
Patent number
US09062015B2

Reaction notes

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