3-Amino-1-propanol → HCID 86671781, compound

HRID 2175111Notes

Reaction equation

HRID 2175111 reaction equation
[Br:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:14][CH2:13][CH2:12][CH:11]([NH:15][CH2:16][CH2:17][CH2:18]CO)[CH2:10][CH2:9]2)[CH:5]=[CH:4][CH:3]=1.NCCC[OH:25]>>[Br:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:14][CH2:13][CH2:12][CH:11]([NH:15][CH2:16][CH2:17][CH2:18][OH:25])[CH2:10][CH2:9]2)[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 77231001HCID 77231001, compound

Product 1

HCID 86671781HCID 86671781, compound

Procedure

The preparation is carried out analogously to 4-[1-(6-bromopyridin-2-yl)azepan-4-ylamino]butan-1-ol starting from 127 μl (1.69 mmol) of 3-amino-1-propanol 524 mg, yellow oil, Rt.=1.59 min (method B), LCMS: 329 (M+H).

Workup

  1. custom=1.59 min (method B), LCMS

Sources & evidence

ORD record
ord-4bd5c634923b412bb419d4b95861d325
Source dataset
uspto-grants-2015_06
Patent number
US09062015B2

Reaction notes

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