Potassium Carbonate → HCID 67247452, compound

HRID 2175117Notes

Reaction equation

HRID 2175117 reaction equation
[CH3:1][C:2]1([CH3:23])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]3[N:16]=[C:15]([N:17]4[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]4)[CH:14]=[CH:13][CH:12]=3)[CH:9]=2)[CH2:4][CH2:3]1.[C:24]([O:27][CH2:28][CH2:29][CH2:30][CH2:31]Br)(=[O:26])[CH3:25].C(=O)([O-])[O-].[K+].[K+]>>[CH3:1][C:2]1([CH3:23])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]3[N:16]=[C:15]([N:17]4[CH2:22][CH2:21][N:20]([CH2:31][CH2:30][CH2:29][CH2:28][O:27][C:24](=[O:26])[CH3:25])[CH2:19][CH2:18]4)[CH:14]=[CH:13][CH:12]=3)[CH:9]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 784911-Butanol, 4-bromo-, 1-acetateHCID 67249071HCID 67249071, compound

Product 1

HCID 67247452HCID 67247452, compound

Procedure

The preparation is carried out analogously to FS401 starting from 142 mg (0.46 mmol) of 1-[6-(3,3-dimethylindan-5-yl)pyridin-2-yl]piperazine and 90 μl of bromobutyl acetate using 2 equiv. of potassium carbonate.

Sources & evidence

ORD record
ord-48bc45f551644ab2bc8747609e5609e7
Source dataset
uspto-grants-2015_06
Patent number
US09062015B2

Reaction notes

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