2,6-Dibromopyridine → tert-Butyl [1-(6-bromopyridin-2-yl)piperidin-3-yl]carbamate

HRID 2175119Notes

Reaction equation

HRID 2175119 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1.[C:9]([O:13][C:14](=[O:22])[NH:15][CH:16]1[CH2:21][CH2:20][CH2:19][NH:18][CH2:17]1)([CH3:12])([CH3:11])[CH3:10]>>[C:9]([O:13][C:14](=[O:22])[NH:15][CH:16]1[CH2:21][CH2:20][CH2:19][N:18]([C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=2)[CH2:17]1)([CH3:12])([CH3:10])[CH3:11]

Participants

3

Reactant 2

HCID 122742,6-DibromopyridineHCID 42330413-(Boc-amino)piperidine

Product 1

HCID 45786980tert-Butyl [1-(6-bromopyridin-2-yl)piperidin-3-yl]carbamate

Procedure

The preparation is carried out analogously starting from 1 g (4.23 mmol) of 2,6-dibromopyridine and 845 mg (4.22 mmol) of piperidin-3-ylcarbamic acid tert-butyl ester.

Sources & evidence

ORD record
ord-2f8ba5772a5a44c0ab5fdbf02b24e4b0
Source dataset
uspto-grants-2015_06
Patent number
US09062015B2

Reaction notes

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