Hydrochloric Acid → HCID 67249448, compound

HRID 2175122Notes

Reaction equation

HRID 2175122 reaction equation
[CH3:1][C:2]1([CH3:27])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([C:14]3[N:19]=[C:18]([N:20]4[CH2:25][CH2:24][CH2:23][CH:22]([NH2:26])[CH2:21]4)[CH:17]=[CH:16][CH:15]=3)[CH:5]=[CH:4][C:3]1=2.Cl[CH2:29][CH2:30][CH2:31][OH:32].Cl>>[CH3:1][C:2]1([CH3:27])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]2[CH:7]=[C:6]([C:14]3[N:19]=[C:18]([N:20]4[CH2:25][CH2:24][CH2:23][CH:22]([NH:26][CH2:29][CH2:30][CH2:31][OH:32])[CH2:21]4)[CH:17]=[CH:16][CH:15]=3)[CH:5]=[CH:4][C:3]1=2

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 123133-Chloro-1-propanolHCID 67248240HCID 67248240, compound

Product 1

HCID 67249448HCID 67249448, compound

Procedure

The preparation is carried out analogously to FS301 starting from 73 mg (0.20 mmol) of 6′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-3,4,5,6-tetrahydro-2H-1,2′-bipyridinyl-3-ylamine and 33 μl of 3-chloro-1-propanol. The product is the hydrochloride.

Sources & evidence

ORD record
ord-5499bf21786144ab9c6c1a40f3835a30
Source dataset
uspto-grants-2015_06
Patent number
US09062015B2

Reaction notes

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