Potassium Carbonate → HCID 67247595, compound

HRID 2175124Notes

Reaction equation

HRID 2175124 reaction equation
[CH3:1][C:2]1([CH3:27])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([C:14]3[N:19]=[C:18]([N:20]4[CH2:26][CH2:25][CH2:24][NH:23][CH2:22][CH2:21]4)[CH:17]=[CH:16][CH:15]=3)[CH:5]=[CH:4][C:3]1=2.[C:28]([O:31][CH2:32][CH2:33][CH2:34][CH2:35]Br)(=[O:30])[CH3:29].C(=O)([O-])[O-].[K+].[K+]>>[CH3:1][C:2]1([CH3:27])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]2[CH:7]=[C:6]([C:14]3[N:19]=[C:18]([N:20]4[CH2:26][CH2:25][CH2:24][N:23]([CH2:35][CH2:34][CH2:33][CH2:32][O:31][C:28](=[O:30])[CH3:29])[CH2:22][CH2:21]4)[CH:17]=[CH:16][CH:15]=3)[CH:5]=[CH:4][C:3]1=2

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 784911-Butanol, 4-bromo-, 1-acetateHCID 67247818HCID 67247818, compound

Product 1

HCID 67247595HCID 67247595, compound

Procedure

The preparation is carried out analogously to FS401 starting from 68 mg (0.19 mmol) of 1-[6-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-pyridin-2-yl]-1,4-diazepane and 34 μl of bromobutyl acetate using 2 equiv. of potassium carbonate.

Sources & evidence

ORD record
ord-c0fd45d88eeb4af798efbe7296841e39
Source dataset
uspto-grants-2015_06
Patent number
US09062015B2

Reaction notes

Loading…