HRID2175161

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID3014186

Ethanol, 2-(aminooxy)-

C2H7NO2

结构：CC(=O)c1ccc2nnc(Sc3ccc4ncc(N5CCN(C)CC5)cc4c3)n2c1

HCID86696294

未命名化合物

PRODUCTS

生成物

$结构：C/C(=N\OCCO)c1ccc2nnc(Sc3ccc4ncc(N5CCN(C)CC5)cc4c3)n2c1$

HCID71537206

未命名化合物

收率 15%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A solution of (86.2) (120 mg, 0.287 mmol) and 2-(aminooxy)ethanol (44.2 mg, 0.573 mmol) in MeOH (10 ml) was added drops of HCl (3 N) to reach pH about 5 and then stirred at rt for overnight. Solvent was evaporated and the residue was purified by preparative base HPLC (gradient eluent NB from 20/80 to 95/5. mobile phase A: NH4OH/CH3CN 0.05%; mobile phase B: NH4OH/H2O 0.05%) to afford the title compound (20 mg, yield 15%).

WORKUP

后处理

customSolvent was evaporated
customthe residue was purified by preparative base HPLC (gradient eluent NB from 20/80 to 95/5. mobile phase A: NH4OH/CH3CN 0.05%; mobile phase B: NH4OH/H2O 0.05%)