2-Bromopropanoyl chloride → 2-Bromo-N-(3-bromo-2-hydroxyphenyl)propionamide

Participants

Reaction Conditions

Reaction Steps

To a mixture of 2-amino-6-bromophenol (3 g, 15.96 mmol) and sodium bicarbonate (3.35 g, 39.9 mmol) in ethyl acetate (30 mL) and water (10 mL) at 0° C. was added 2-bromopropionyl chloride (1.61 ml, 15.96 mmol) dropwise. The reaction mixture was stirred at 0° C. for 3 h and then diluted with water. The resulting mixture was extracted with EtOAc and the organic layer was washed with brine, dried over anhydrous MgSO4, filtered, and concentrated to afford the title compound (4.7 g, 73% yield). LCMS, [M+H]+=323.8.

Provenance & Evidence