反应详情

温度

0 °C

To a mixture of 2-amino-6-bromophenol (3 g, 15.96 mmol) and sodium bicarbonate (3.35 g, 39.9 mmol) in ethyl acetate (30 mL) and water (10 mL) at 0° C. was added 2-bromopropionyl chloride (1.61 ml, 15.96 mmol) dropwise. The reaction mixture was stirred at 0° C. for 3 h and then diluted with water. The resulting mixture was extracted with EtOAc and the organic layer was washed with brine, dried over anhydrous MgSO4, filtered, and concentrated to afford the title compound (4.7 g, 73% yield). LCMS, [M+H]+=323.8.

1. extractionThe resulting mixture was extracted with EtOAc
2. washthe organic layer was washed with brine
3. dry with materialdried over anhydrous MgSO4
4. filtrationfiltered
5. concentrationconcentrated