反应详情

温度

0 °C

To a solution of 4-(2,3-dimethylphenoxy)-1-(5-(1-(3-(2-hydroxyethoxy)benzyl)-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)butan-1-one (0.07 g, 0.13 mmol) in CH2Cl2 (2 mL) at 0° C. was added methanesulfonyl chloride (0.019 g, 0.17 mmol) and triethylamine (0.029 mL, 0.21 mmol) dropwise. The reaction mixture was stirred at 0° C. for 2 h and then quenched with saturated NaHCO3. The resulting mixture was extracted with ethyl acetate. The organic layer was washed with 1 N HCl, saturated NaHCO3, and brine, dried and concentrated to afford the title compound (80 mg, 100%). LCMS, [M+H]+=618.4.

1. customquenched with saturated NaHCO3
2. extractionThe resulting mixture was extracted with ethyl acetate
3. washThe organic layer was washed with 1 N HCl, saturated NaHCO3, and brine
4. customdried
5. concentrationconcentrated