反应详情

To a solution of 4-(2,3-dimethylphenoxy)-1-(5-(1-(3-(2-hydroxyethoxy)benzyl)-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)butan-1-one (0.02 g, 0.037 mmol), 1,3-bis(tert-butoxycarbonyl)-guanidine (0.024 g, 0.093 mmol), triphenylphosphine (0.024 g, 0.093 mmol) in DCM (0.1 mL) was added DEAD (0.040 g, 0.093 mmol, 40% wt in toluene). The reaction mixture was stirred at room temperature for 1 h and then concentrated. The resulting residue was purified by flash chromatography (0-100% ethyl acetate:hexanes) to afford the title compound (0.026 g, 90% yield) as a white powder. LCMS, [M+H]+=781.3.

1. concentrationconcentrated
2. customThe resulting residue was purified by flash chromatography (0-100% ethyl acetate:hexanes)