反应详情

A solution of compound 8-2 (135 mg, 0.652 mmol) and 4,6-dichloro-2-methylpyrimidine (106.3 mg, 0.65 mmol) in THF (3.0 mL) was treated with Cs2CO3 (281 mg, 0.86 mmol) and heated to reflux for 12 h. The reaction mixture was filtrated and the filtrate was concentrated and purified directly by gradient elution on silica gel (Petroleum ether:ethyl acetate=2:1-1:1) to afford the title compound as a colorless oil (60 mg, 28%). LRMS (ES) calculated M+H for C17H20ClN3O2: 334.12. Found: 334.1.

1. temperatureheated
2. temperatureto reflux for 12 h
3. filtrationThe reaction mixture was filtrated
4. concentrationthe filtrate was concentrated
5. custompurified directly by gradient elution on silica gel (Petroleum ether:ethyl acetate=2:1-1:1)