HCID 56925554, compound → HCID 56925555, compound

HRID 2175454Notes

Reaction equation

HRID 2175454 reaction equation
[CH3:1][C:2]([O:7][C:8]1[CH:15]=[CH:14][C:11]([CH:12]=[O:13])=[CH:10][CH:9]=1)([CH2:5][CH3:6])[C:3]#[CH:4]>C1(C)C(C)=CC=CC=1>[CH2:3]([C:2]1([CH3:1])[CH:5]=[CH:6][C:9]2[C:8](=[CH:15][CH:14]=[C:11]([CH:12]=[O:13])[CH:10]=2)[O:7]1)[CH3:4]

Participants

3

Reactant 1

HCID 56925554HCID 56925554, compound

Product 1

HCID 56925555HCID 56925555, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A solution of 7 (170 mg) in xylene (3 mL) was subjected to microwave irradiation for 100 min at 220 W, 200 torr, 120° C. The solvent was removed in vacuum to give a quantitative yield of the product (170 mg). 1H NMR (CDCl3): δ 9.81 (s, 1H), 7.63 (dd, J=8.0 Hz, 2.0 Hz, 1H), 7.50 (d, J=2.0 Hz, 1H), 6.85 (d, J=8.4 Hz, 1H), 6.42 (d, J=10.0 Hz, 1H), 5.62 (d, J=10.0 Hz, 1H), 1.81-1.66 (m, 3H), 1.43 (s, 3H), 0.97 ppm (t, J=7.6 Hz, 3H).

Workup

  1. customirradiation for 100 min at 220 W, 200 torr, 120° C
  2. customThe solvent was removed in vacuum

Sources & evidence

ORD record
ord-bdac490df5cf4aefad79524a9c0ad326
Source dataset
uspto-grants-2015_06
Patent number
US09062072B2

Reaction notes

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