Hydrochloric Acid → 4-(4-Oxocyclohexyl)-1,3-oxazinan-2-one

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Reaction Steps

A 250 mL round bottom flask was charge with 4-(1,4-dioxaspiro[4.5]decan-8-yl)-1,3-oxazinan-2-one (1.39 g, 5.76 mmol) and acetonitrile (96 mL). A solution of concentrated HCl (6.4 mL) in water (19 mL) was added to the mixture. The mixture was stirred at room temperature for 20 h. Saturated aqueous ammonium bicarbonate was added until the pH was >7. The mixture was extracted with ethyl acetate. Dry organic layer with MgSO4, filter, and concentrate in vacuo to give the target material as a clear oil.

Provenance & Evidence