反应详情

温度

80 °C

8-(oxiran-2-yl)-1,4-dioxaspiro[4.5]decane (202 mg, 1.10 mmol), prepared in the previous step, in DCM (20 mL) was dissolved in NMP (20 mL) and methanethiol sodium salt (297 mg, 4.24 mmol) was added. The mixture was stirred, heating to 80° C. under argon overnight and then cooled to ambient temperature and poured onto water. After extraction with ethyl acetate, the organic layers were concentrated in vacuo and the residue was purified by flash chromatography (silica gel, 0-50% ether) to afford the product.

1. temperaturecooled to ambient temperature
2. additionpoured onto water
3. extractionAfter extraction with ethyl acetate
4. concentrationthe organic layers were concentrated in vacuo
5. customthe residue was purified by flash chromatography (silica gel, 0-50% ether)
6. customto afford the product