反应详情

A solution of 4-((4-methoxybenzyl)oxy)-6-(trifluoromethyl)quinoline-2-carboxamide (9 g, 24 mmol) from above step B, and TEA (10 mL, 72 mmol) was treated with trifluoroacetic anhydride (4.35 mL, 31.3 mmol) at room temperature and stirred for 2 h (completion of reaction monitored by LCMS). Solvent was removed under vacuum and the residue was purified by recrystallization from EtOAc/Hex to give the title compound.

1. custom(completion of reaction monitored by LCMS)
2. customSolvent was removed under vacuum
3. customthe residue was purified by recrystallization from EtOAc/Hex