Hydrochloric Acid → 1-1,4-Dioxaspiro[4.5]decan-8-ylpropan-1-amine hydrochloride

HRID 2175591Notes

Reaction equation

HRID 2175591 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][CH:8]([CH:11]([NH:14]S(C(C)(C)C)=O)[CH2:12][CH3:13])[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.[ClH:21]>CO>[ClH:21].[O:1]1[C:5]2([CH2:10][CH2:9][CH:8]([CH:11]([NH2:14])[CH2:12][CH3:13])[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58562811HCID 58562811, compound

Product 1

HCID 680037861-1,4-Dioxaspiro[4.5]decan-8-ylpropan-1-amine hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of N-(1-(1,4-dioxaspiro[4.5]decan-8-yl)propyl)-2-methylpropane-2-sulfinamide (as prepared in the previous step, 2.55 g, 8.39 mmol) in dry MeOH (50 mL) was added HCl (14 mL, 17.5 mmol, 1.25 M in MeOH) at room temperature. After stirring overnight at ambient temperature, the reaction mixture was concentrated in vacuo. Trituration of the residue with ether, followed by decantation of the supernatant and drying the residue under high vacuum afforded the product as a white foam.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo
  2. customdrying the residue under high vacuum

Sources & evidence

ORD record
ord-7fe46654bc3544a3beb8b773b5a398c0
Source dataset
uspto-grants-2015_06
Patent number
US09062048B2

Reaction notes

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