反应详情

温度

90 °C

Into a 50 mL round-bottom flask, was placed a solution of 3-(trifluoromethyl)-1,6-naphthyridin-5(6H)-one (as prepared in the previous step, 1 g, 4.67 mmol, 1.00 equiv) in acetonitrile (10 mL) and phosphoryl trichloride (10 mL). The reaction mixture was stirred for 2 h at 90° C. in an oil bath. The resulting mixture was concentrated under vacuum. The residue was purified by chromatography over a silica gel column with ethyl acetate/petroleum ether (1:20). The title compound was obtained as a yellow solid.

1. customInto a 50 mL round-bottom flask, was placed
2. concentrationThe resulting mixture was concentrated under vacuum
3. customThe residue was purified by chromatography over a silica gel column with ethyl acetate/petroleum ether (1:20)