Trifluoroacetic acid → HCID 68003861, compound

HRID 2175629Notes

Reaction equation

HRID 2175629 reaction equation
[F:1][C:2]([F:30])([F:29])[C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[N:8][N:9]=[C:10]2[NH:13][CH2:14][C:15]([NH:17][CH:18]2[CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19]2)=[O:16])=[CH:5][CH:4]=1.FC(F)(F)C(O)=O>ClCCl>[NH:20]1[CH2:19][CH:18]([NH:17][C:15](=[O:16])[CH2:14][NH:13][C:10]2[C:11]3[C:6](=[CH:5][CH:4]=[C:3]([C:2]([F:1])([F:30])[F:29])[CH:12]=3)[CH:7]=[N:8][N:9]=2)[CH2:21]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68003886HCID 68003886, compound

Product 1

HCID 68003861HCID 68003861, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

Into a 25 mL round-bottom flask, was placed a solution of tert-butyl 3-(2-(7-(trifluoromethyl)phthalazin-1-ylamino)acetamido)azetidine-1-carboxylate (prepared as described in the previous step, 160 mg, 0.38 mmol, 1.00 equiv) in dichloromethane (1 mL). This was followed by the addition of trifluoroacetic acid (0.8 mL). The reaction mixture was stirred for 2 h at 0° C. The resulting mixture was concentrated under vacuum. The title compound was obtained as a yellow oil.

Workup

  1. customInto a 25 mL round-bottom flask, was placed
  2. concentrationThe resulting mixture was concentrated under vacuum

Sources & evidence

ORD record
ord-589f36872a1042c5847d2dc9d7d690a9
Source dataset
uspto-grants-2015_06
Patent number
US09062048B2

Reaction notes

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