HCID 86727040, compound → HCID 89633271, compound

HRID 2175795Notes

Reaction equation

HRID 2175795 reaction equation
[CH3:1][C:2]1[C:10]([C@H:11]2[CH2:16][N:15]3[CH2:17][CH2:18][N:19](C(OCC4C=CC=CC=4)=O)[CH2:20][C@H:14]3[CH2:13][N:12]2[C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][O:5][C:6]2=[O:38]>CO.[Pd]>[CH3:1][C:2]1[C:10]([C@H:11]2[CH2:16][N:15]3[CH2:17][CH2:18][NH:19][CH2:20][C@H:14]3[CH2:13][N:12]2[C:31]([O:33][C:34]([CH3:36])([CH3:35])[CH3:37])=[O:32])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][O:5][C:6]2=[O:38]

Participants

4

Reactant 1

HCID 86727040HCID 86727040, compound

Product 1

HCID 89633271HCID 89633271, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of the title compound of Step D ((0.46 g, 0.88 mmol) in methanol (30 mL) was added palladium on carbon (10%, 0.094 g, 0.088 mmol) and the mixture was subjected to hydrogenation at rt overnight. After filtration the filtrate was concentrated to give the title compound. LC/MS: (M+1)+: 388.10.

Workup

  1. filtrationAfter filtration the filtrate
  2. concentrationwas concentrated

Sources & evidence

ORD record
ord-b32272001023467e9af099a0b7eb4050
Source dataset
uspto-grants-2015_06
Patent number
US09062070B2

Reaction notes

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