HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate → (3S,9aR)-tert-butyl 3-(3-cyano-4-fluoro-2-methylphenyl)hexahydro-1H-pyrazino[1,2-a]pyrazine-2(6H)-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate | HCID 24820286 | — |
| Reactant | 6-Fluoro-2-methyl-3-(oxiran-2-yl)benzonitrile | HCID 86647307 | — |
| Reactant | (3R,9aS)-tert-butyl 3-(3-cyano-4-fluoro-2-methylphenyl)hexahydro-1H-pyrazino[1,2-a]pyrazine-2(6H)-carboxylate | HCID 86727053 | — |
| Product | (3S,9aR)-tert-butyl 3-(3-cyano-4-fluoro-2-methylphenyl)hexahydro-1H-pyrazino[1,2-a]pyrazine-2(6H)-carboxylate | HCID 86727055 | — |
Reaction Steps
The title compound was prepared in an analogous fashion to that described for the synthesis of (3R,9aS)-tert-butyl 3-(3-cyano-4-fluoro-2-methylphenyl)hexahydro-1H-pyrazino[1,2-a]pyrazine-2(6H)-carboxylate starting from 6-fluoro-2-methyl-3-(oxiran-2-yl)benzonitrile and (R)-tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate. LC/MS: 375.16 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09062070B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-814d3254b2714c6f92286eee4bd6d044 |
| Source note | uspto-grants-2015_06 |