HCID 66643955, compound → HCID 66643986, compound

HRID 2175887Notes

Reaction equation

HRID 2175887 reaction equation
[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[O:7][CH2:8][C:4]=2[C:3]=1[CH:12]=[CH2:13]>CO.[Pd]>[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[O:7][CH2:8][C:4]=2[C:3]=1[CH2:12][CH3:13]

Participants

4

Reactant 1

HCID 66643955HCID 66643955, compound

Product 1

HCID 66643986HCID 66643986, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 5-bromo-4-vinyl-2-benzofuran-1(3H)-one (2.0 g, 8.37 mmol) and Pd/C (400 mg) in 50 mL of MeOH was stirred at rt under H2 (1 atm) overnight, and then filtered. The filtrate was concentrated. The resulting material was purified by column chromatography to give 5-bromo-4-ethyl-2-benzofuran-1(3H)-one.

Workup

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated
  3. customThe resulting material was purified by column chromatography

Sources & evidence

ORD record
ord-aa1de4229087499b8a53610f156878c2
Source dataset
uspto-grants-2015_06
Patent number
US09062070B2

Reaction notes

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