HCID 71270731, compound → HCID 86727107, compound

HRID 2175922Notes

Reaction equation

HRID 2175922 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[CH2:12][CH2:11][CH:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:7]2=[N:8][CH:9]=1)([O-])=O.[H][H]>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[CH2:12][CH2:11][CH:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:7]2=[N:8][CH:9]=1

Participants

5

Reactant 2

HCID 71270731HCID 71270731, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 86727107HCID 86727107, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of ethyl 3-nitro-6,7-dihydro-5H-cyclopenta[b]pyridine-7-carboxylate (4.2 g, 17.8 mmol) and Pd/C (0.5 g, 10%) in 80 mL of ethanol was stirred at room temperature under 50 psi of hydrogen for 2 hours then filtered. The filtrate was concentrated to afford the title compound.

Workup

  1. filtrationthen filtered
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-058cbfafeec940d7ac097bbd727a210a
Source dataset
uspto-grants-2015_06
Patent number
US09062070B2

Reaction notes

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