7-Methoxyquinoline-8-carboxylic acid → 7-Hydroxyquinoline-8-carboxylic acid

HRID 2175943Notes

Reaction equation

HRID 2175943 reaction equation
C[O:2][C:3]1[C:12]([C:13]([OH:15])=[O:14])=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1>Br>[OH:2][C:3]1[C:12]([C:13]([OH:15])=[O:14])=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1

Participants

3

Reactant 1

HCID 687745837-Methoxyquinoline-8-carboxylic acid

Product 1

HCID 1358815557-Hydroxyquinoline-8-carboxylic acid

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

The title compound of Step A (2.9 g, 14.1 mmol) in HBr (14 mL) was heated at 90° C. for 1 h. The mixture was then concentrated washed with PhCH3 and used without further purification in subsequent steps.

Workup

  1. concentrationThe mixture was then concentrated
  2. washwashed with PhCH3
  3. customused without further purification in subsequent steps

Sources & evidence

ORD record
ord-fca294ba5ead4eac93e5bd47c84c94b0
Source dataset
uspto-grants-2015_06
Patent number
US09062078B2

Reaction notes

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