ethyl 3-(2H-1,2,3-triazol-2-yl)quinoline-2-carboxylate → 3,6'-Dimethyl-[2,3'-bipyridine]-2'-carboxylic acid

HRID 2175954Notes

Reaction equation

HRID 2175954 reaction equation
N1N(C2C(C(OCC)=O)=NC3C(C=2)=CC=CC=3)N=CC=1.[CH3:21][C:22]1[C:23]([C:28]2[C:29]([C:35]([O:37]C)=[O:36])=[N:30][C:31]([CH3:34])=[CH:32][CH:33]=2)=[N:24][CH:25]=[CH:26][CH:27]=1>>[CH3:21][C:22]1[C:23]([C:28]2[C:29]([C:35]([OH:37])=[O:36])=[N:30][C:31]([CH3:34])=[CH:32][CH:33]=2)=[N:24][CH:25]=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 90411115ethyl 3-(2H-1,2,3-triazol-2-yl)quinoline-2-carboxylateHCID 90412135Methyl 3,6'-dimethyl-[2,3'-bipyridine]-2'-carboxylate

Product 1

HCID 904125653,6'-Dimethyl-[2,3'-bipyridine]-2'-carboxylic acid

Procedure

Prepared analogous to intermediate A-33 step B substituting ethyl 3-(2H-1,2,3-triazol-2-yl)quinoline-2-carboxylate with the title compound of step D. MS (ESI) mass calcd. for C13H12N2O2, 228.2; m/z found 229 [M+H]+.

Workup

  1. customPrepared analogous to intermediate A-33 step B

Sources & evidence

ORD record
ord-da06dbb7ee854a6fb1f1896453363d60
Source dataset
uspto-grants-2015_06
Patent number
US09062078B2

Reaction notes

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