Hydrochloric Acid → HCID 90412405, compound

HRID 2175963Notes

Reaction equation

HRID 2175963 reaction equation
[CH3:1][C:2]1[N:7]=C(C#N)[C:5]([N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:4][CH:3]=1.[OH-:15].[K+].Cl.[CH3:18][CH2:19][OH:20]>>[CH3:1][C:2]1[N:7]=[C:18]([C:19]([OH:15])=[O:20])[C:5]([N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:4][CH:3]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium Hydroxide2×HCID 90411601HCID 90411601, compound

Product 1

HCID 90412405HCID 90412405, compound

Conditions

Temperature
90 °C

Procedure

To the title compound of Step A (162 mg, 0.9 mmol) in EtOH (2.6 mL) was added 4M KOH (650 μL, 2.6 mmol). The reaction was then heated at 90° C. for 18 h. Additional 4M KOH (1.5 mL, 6 mmol) was added and heating continued overnight. The reaction was then cooled to rt, acidified with 1N HCl (aq), concentrated and used without further purification in the next step.

Workup

  1. temperatureheating continued overnight
  2. temperatureThe reaction was then cooled to rt
  3. concentrationconcentrated
  4. customused without further purification in the next step

Sources & evidence

ORD record
ord-abfe6e8f2f544fa1b1f986d7ac74ca02
Source dataset
uspto-grants-2015_06
Patent number
US09062078B2

Reaction notes

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