Hydrochloric Acid → HCID 90411275, compound

HRID 2175979Notes

Reaction equation

HRID 2175979 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]1[N:4]=[CH:5][C:6]([NH:9][C@@H:10]2[CH2:15][C@@H:14]3[N:16](C(OC(C)(C)C)=O)[C@H:11]2[CH2:12][CH2:13]3)=[N:7][CH:8]=1.[ClH:26]>C(Cl)Cl.O1CCOCC1>[ClH:26].[F:25][C:2]([F:1])([F:24])[C:3]1[N:4]=[CH:5][C:6]([NH:9][C@@H:10]2[CH2:15][C@@H:14]3[NH:16][C@H:11]2[CH2:12][CH2:13]3)=[N:7][CH:8]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 90413114HCID 90413114, compound

Product 1

HCID 90411275HCID 90411275, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To the intermediate of Example 181 Step A (100 mg, 0.3 mmol) in DCM (3 mL) was added 4M HCl in dioxane (0.8 mL). The reaction was allowed to proceed overnight then concentrated neutralized with 5% Na2CO3 (aq) and extracted with DCM (2×). The combined organics were dried (Na2SO4) to give the title compound of step A that was used without further purification.

Workup

  1. concentrationthen concentrated
  2. extractionextracted with DCM (2×)
  3. dry with materialThe combined organics were dried (Na2SO4)

Sources & evidence

ORD record
ord-1eeccaffa41047baa80d0557300d5d1a
Source dataset
uspto-grants-2015_06
Patent number
US09062078B2

Reaction notes

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