反应详情

5-[6-(3-Methoxy-prop-1-ynyl)-pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine (43, 0.534 g, 2.03 mmol) was dissolved in 8.1 mL of methanol. Palladium hydroxide (0.028 g, 0.20 mmol) was added, and the resulting mixture was stirred under an atmosphere of hydrogen for a few hours, then filtered through a bed of celite. The filtrate was concentrated under vacuum. The crude material was purified by silica gel flash chromatography eluting with ethyl acetate and hexane. The appropriate fractions were combined and the solvents removed under vacuum to provide the desired compound (44, 419 g). MS (ESI) [M+H+]+=268.3.

1. filtrationfiltered through a bed of celite
2. concentrationThe filtrate was concentrated under vacuum
3. customThe crude material was purified by silica gel flash chromatography
4. washeluting with ethyl acetate and hexane
5. customthe solvents removed under vacuum