Hydrogen chloride-ethyl acetate → HCID 90370286, compound

HRID 2176012Notes

Reaction equation

HRID 2176012 reaction equation
[N:1]1([CH2:13][C:14]([O:16]C(C)(C)C)=[O:15])[CH2:6][CH2:5][N:4]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:3][CH2:2]1.[ClH:21].C(OCC)(=O)C>>[ClH:21].[ClH:21].[CH2:11]([O:10][C:8](=[O:9])[CH2:7][N:4]1[CH2:5][CH2:6][N:1]([CH2:13][C:14]([OH:16])=[O:15])[CH2:2][CH2:3]1)[CH3:12]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 89534615HCID 89534615, compound

Product 1

HCID 90370286HCID 90370286, compound

Procedure

To 4.8 g of tert-butyl ethyl 2,2′-piperazine-1,4-diyldiacetate was added 20 mL of a 4M hydrogen chloride/ethyl acetate solution, followed by stirring for 2 hours at room temperature. The generated insoluble material was collected by filtration, thereby obtaining 4.0 g of [4-(2-ethoxy-2-oxoethyl)piperazin-1-yl]acetic acid dihydrochloride.

Workup

  1. filtrationThe generated insoluble material was collected by filtration

Sources & evidence

ORD record
ord-b5deaef227844b1dbe506e7d78094fb3
Source dataset
uspto-grants-2015_06
Patent number
US09062032B2

Reaction notes

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