3-Aminopyridine → HCID 90370152, compound

HRID 2176021Notes

Reaction equation

HRID 2176021 reaction equation
[CH:1]([C:3]1[CH:4]=[C:5]([CH:15]=[CH:16][CH:17]=1)[C:6]([O:8][CH2:9][CH2:10][Si:11]([CH3:14])([CH3:13])[CH3:12])=[O:7])=O.[NH2:18][C:19]1[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=1>>[N:21]1[CH:22]=[CH:23][CH:24]=[C:19]([NH:18][CH2:1][C:3]2[CH:4]=[C:5]([CH:15]=[CH:16][CH:17]=2)[C:6]([O:8][CH2:9][CH2:10][Si:11]([CH3:14])([CH3:13])[CH3:12])=[O:7])[CH:20]=1

Participants

3

Reactant 2

HCID 100093-AminopyridineHCID 90370263HCID 90370263, compound

Product 1

HCID 90370152HCID 90370152, compoundYield 77%

Procedure

By using 500 mg of 2-(trimethylsilyl)ethyl 3-formylbenzoate and 188 mg of 3-aminopyridine, the reaction similar to Preparation Example 14 was performed, thereby obtaining 505 mg of 2-(trimethylsilyl)ethyl 3-[(pyridin-3-ylamino)methyl]benzoate.

Workup

  1. customthe reaction
  2. customsimilar to Preparation Example 14

Sources & evidence

ORD record
ord-29d4d6565d844a019e06085d8189efe1
Source dataset
uspto-grants-2015_06
Patent number
US09062032B2

Reaction notes

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