Triphenylphosphine → HCID 90370141, compound

HRID 2176034Notes

Reaction equation

[Br:1][CH2:2][C:3]1[S:7][C:6]([C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:9])=[CH:5][CH:4]=1.[C:18]1([P:24]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C1(C)C=CC=CC=1>[Br-:1].[CH2:11]([O:10][C:8]([C:6]1[S:7][C:3]([CH2:2][P+:24]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)=[CH:4][CH:5]=1)=[O:9])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

Conditions

Temperature: 80 °C

Procedure

To a mixture of 2.18 g of benzyl 5-(bromomethyl)thiophene-2-carboxylate and 26 mL of toluene was added 1.86 g of triphenylphosphine, followed by stirring overnight at 80° C. The insoluble material was collected by filtration, thereby obtaining 2.89 g of ({5-[(benzyloxy)carbonyl]-2-thienyl}methyl)(triphenyl)phosphonium bromide.

Workup

filtrationThe insoluble material was collected by filtration

Sources & evidence

ORD record: ord-0c67f94b474e4838bf26cd39989f6f58
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09062032B2

Reaction notes

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