Morpholine → HCID 90370137, compound

HRID 2176036Notes

Reaction equation

HRID 2176036 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[N:4][CH:3]=1.C1C(=O)N(Br)C(=O)C1.[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>>[N:20]1([CH2:1][C:2]2[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[N:4][CH:3]=2)[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1

Participants

4

Reactant 3

HCID 8083MorpholineHCID 67184N-bromobutanimideHCID 13153470Methyl 6-methylpyrazine-2-carboxylate

Product 1

HCID 90370137HCID 90370137, compound

Procedure

By using 3.42 g of methyl 6-methylpyrazine-2-carboxylate and 4.40 g of NBS, a bromination reaction was performed by the method similar to Preparation Example 62. Thereafter, by using 10 mL of morpholine as amine, the reaction similar to Preparation Example 9 was performed, thereby obtaining 987 mg of methyl 6-(morpholin-4-ylmethyl)pyrazine-2-carboxylate.

Workup

  1. customa bromination reaction
  2. customwas performed by the method similar to Preparation Example 62
  3. customthe reaction
  4. customsimilar to Preparation Example 9

Sources & evidence

ORD record
ord-30fb0a6af9c84d4e9cb3e4b9415d4e84
Source dataset
uspto-grants-2015_06
Patent number
US09062032B2

Reaction notes

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