1-[4-(Cyclopropylamino)piperidin-1-yl]ethan-1-one → HCID 90370134, compound

HRID 2176054Notes

Reaction equation

HRID 2176054 reaction equation
Cl[CH2:2][C:3]1[CH:4]=[C:5]([CH:32]=[CH:33][CH:34]=1)[C:6]([NH:8][C:9]1[S:10][C:11]2[CH2:31][CH2:30][CH2:29][CH2:28][C:12]=2[C:13]=1[C:14]([NH:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]([CH2:26][CH3:27])[CH2:24][CH3:25])=[CH:19][CH:18]=1)=[O:15])=[O:7].[CH:35]1([NH:38][CH:39]2[CH2:44][CH2:43][N:42]([C:45](=[O:47])[CH3:46])[CH2:41][CH2:40]2)[CH2:37][CH2:36]1>>[C:45]([N:42]1[CH2:41][CH2:40][CH:39]([N:38]([CH2:2][C:3]2[CH:4]=[C:5]([CH:32]=[CH:33][CH:34]=2)[C:6]([NH:8][C:9]2[S:10][C:11]3[CH2:31][CH2:30][CH2:29][CH2:28][C:12]=3[C:13]=2[C:14]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([N:23]([CH2:26][CH3:27])[CH2:24][CH3:25])=[CH:19][CH:18]=2)=[O:15])=[O:7])[CH:35]2[CH2:37][CH2:36]2)[CH2:44][CH2:43]1)(=[O:47])[CH3:46]

Participants

3

Reactant 2

HCID 27352411-[4-(Cyclopropylamino)piperidin-1-yl]ethan-1-oneHCID 90370188HCID 90370188, compound

Product 1

HCID 90370134HCID 90370134, compoundYield 77.7%

Procedure

By using 5.34 g of 2-{[3-(chloromethyl)benzoyl]amino}-N-[4-(diethylamino)phenyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide and 13.1 g of 1-[4-(cyclopropylamino)piperidin-1-yl]ethanone as starting materials, a reaction was performed under the conditions similar to Preparation Example 29, thereby obtaining 5.37 g of 2-[(3-{[(1-acetylpiperidin-4-yl)(cyclopropyl)amino]methyl}benzoyl)amino]-N-[4-(diethylamino)phenyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide.

Workup

  1. customa reaction was performed under the conditions similar to Preparation Example 29

Sources & evidence

ORD record
ord-d7b2f64a017d46b8b4b50cc777f4f118
Source dataset
uspto-grants-2015_06
Patent number
US09062032B2

Reaction notes

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