Dimethylformamide → HCID 58336758, compound

HRID 2176406Notes

Reaction equation

HRID 2176406 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][CH:3]=1.[CH3:10][N:11]([CH:13]=O)[CH3:12]>>[CH3:10][N:11]([CH3:13])/[CH:12]=[CH:1]/[C:2]1[N:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6228DimethylformamideHCID 741826-Methylpyridine-2-carbonitrile

Product 1

HCID 58336758HCID 58336758, compound

Procedure

20 g (169 mmol) of 6-methylpyridine-2-carbonitrile were reacted in a mixture of in each case 100 ml of DMF and DMF-dimethyl acetal in an autoclave at 175° C. overnight. After cooling, the mixture was concentrated by evaporation, the residue was dissolved in dichloromethane, the solution was filtered, the filtrate was concentrated and the residue was subjected to distillation under reduced pressure in a kugelrohr.

Workup

  1. temperatureAfter cooling
  2. concentrationthe mixture was concentrated by evaporation
  3. dissolutionthe residue was dissolved in dichloromethane
  4. filtrationthe solution was filtered
  5. concentrationthe filtrate was concentrated
  6. distillationthe residue was subjected to distillation under reduced pressure in a kugelrohr

Sources & evidence

ORD record
ord-f225c08ddccf4ff7b75aa7495d2a80e4
Source dataset
uspto-grants-2015_06
Patent number
US09066518B2

Reaction notes

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