HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(4-Oxo-3,4-dihydroquinazolin-6-yl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 2-(4-oxo-3,4-dihydroquinazolin-6-yl)acetate | HCID 136387213 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(4-Oxo-3,4-dihydroquinazolin-6-yl)acetic acid | HCID 136026471 | — |
Reaction Steps
A solution of tert-butyl 2-(4-oxo-3,4-dihydroquinazolin-6-yl)acetate (0.25 g, 0.96 mmol) in 10 mL of satd. HCl in EtOAc was stirred at rt for 4 hours. The mixture was concentrated in vacuo at rt, and the residue was used in the next reaction without further purification. MS (ESI, pos. ion) m/z: 205.1 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09066954B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-5bb46bd1eaef493fa777ab6b59df5de0 |
| Source note | uspto-grants-2015_06 |