Hydrochloric Acid → 2-(4-Oxo-3,4-dihydroquinazolin-6-yl)acetic acid

HRID 2176539Notes

Reaction equation

HRID 2176539 reaction equation
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH2:12][C:13]([O:15]C(C)(C)C)=[O:14])[CH:10]=2)[N:5]=[CH:4][NH:3]1.Cl>CCOC(C)=O>[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH2:12][C:13]([OH:15])=[O:14])[CH:10]=2)[N:5]=[CH:4][NH:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 136387213Tert-butyl 2-(4-oxo-3,4-dihydroquinazolin-6-yl)acetate

Product 1

HCID 1360264712-(4-Oxo-3,4-dihydroquinazolin-6-yl)acetic acid

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of tert-butyl 2-(4-oxo-3,4-dihydroquinazolin-6-yl)acetate (0.25 g, 0.96 mmol) in 10 mL of satd. HCl in EtOAc was stirred at rt for 4 hours. The mixture was concentrated in vacuo at rt, and the residue was used in the next reaction without further purification. MS (ESI, pos. ion) m/z: 205.1 (M+1).

Workup

  1. concentrationThe mixture was concentrated in vacuo at rt
  2. customthe residue was used in the next reaction without further purification

Sources & evidence

ORD record
ord-5bb46bd1eaef493fa777ab6b59df5de0
Source dataset
uspto-grants-2015_06
Patent number
US09066954B2

Reaction notes

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