1-(4-Fluorophenyl)piperazine → HCID 59168069, compound

HRID 217660Notes

Reaction equation

HRID 217660 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([N:9]=[C:10]=[N:11][C:12]2[CH:17]=[CH:16][N:15]=[CH:14][C:13]=2/[CH:18]=[CH:19]/[C:20]([O:22][CH3:23])=[O:21])[CH:6]=[CH:7][CH:8]=1.[F:26][C:27]1[CH:32]=[CH:31][C:30]([N:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)=[CH:29][CH:28]=1>>[F:26][C:27]1[CH:28]=[CH:29][C:30]([N:33]2[CH2:38][CH2:37][N:36]([C:10]3[N:9]([C:5]4[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:24])([F:1])[F:25])[CH:4]=4)[CH:18]([CH2:19][C:20]([O:22][CH3:23])=[O:21])[C:13]4[CH:14]=[N:15][CH:16]=[CH:17][C:12]=4[N:11]=3)[CH2:35][CH2:34]2)=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 752601-(4-Fluorophenyl)piperazineHCID 86620419HCID 86620419, compound

Product 1

HCID 59168069HCID 59168069, compound

Procedure

Starting from 107 mg (0.31 mmol) of the carbodiimide from Example 15A and 56 mg (0.31 mmol) of 4-fluorophenylpiperazine, general procedure [C] and purification by preparative HPLC result in 50 mg (28% of theory) of product.

Workup

  1. customresult in 50 mg (28% of theory) of product

Sources & evidence

ORD record
ord-348c5c2394314d20b522e2134ebc4c3f
Source dataset
uspto-grants-2012_06
Patent number
US08198282B2

Reaction notes

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