1-(4-Fluorophenyl)piperazine → HCID 59168054, compound

HRID 217662Notes

Reaction equation

HRID 217662 reaction equation
[F:1][C:2]([F:28])([F:27])[C:3]1[CH:4]=[C:5]([N:9]=[C:10]=[N:11][C:12]2[C:13](/[CH:18]=[CH:19]/[C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])=[N:14][CH:15]=[CH:16][CH:17]=2)[CH:6]=[CH:7][CH:8]=1.[F:29][C:30]1[CH:35]=[CH:34][C:33]([N:36]2[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]2)=[CH:32][CH:31]=1>>[F:29][C:30]1[CH:31]=[CH:32][C:33]([N:36]2[CH2:41][CH2:40][N:39]([C:10]3[N:9]([C:5]4[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:27])([F:1])[F:28])[CH:4]=4)[CH:18]([CH2:19][C:20]([O:22][C:23]([CH3:25])([CH3:24])[CH3:26])=[O:21])[C:13]4[N:14]=[CH:15][CH:16]=[CH:17][C:12]=4[N:11]=3)[CH2:38][CH2:37]2)=[CH:34][CH:35]=1

Participants

3

Reactant 2

HCID 752601-(4-Fluorophenyl)piperazineHCID 86620418HCID 86620418, compound

Product 1

HCID 59168054HCID 59168054, compound

Procedure

Starting from 53 mg (0.14 mmol) of the carbodiimide from Example 14A and 24 mg (0.14 mmol) of 4-fluorophenylpiperazine, general procedure [C] and purification on preparative HPLC result in 38 mg (48% of theory) of product.

Workup

  1. customresult in 38 mg (48% of theory) of product

Sources & evidence

ORD record
ord-2572a27b5faf40e4847fc82348e49622
Source dataset
uspto-grants-2012_06
Patent number
US08198282B2

Reaction notes

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