1-(4-Fluorophenyl)piperazine → HCID 59168066, compound

HRID 217664Notes

Reaction equation

HRID 217664 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][C:4]=1[N:13]=[C:14]=[N:15][C:16]1[CH:21]=[CH:20][N:19]=[CH:18][C:17]=1/[CH:22]=[CH:23]/[C:24]([O:26][CH3:27])=[O:25].[F:28][C:29]1[CH:34]=[CH:33][C:32]([N:35]2[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]2)=[CH:31][CH:30]=1>>[F:28][C:29]1[CH:30]=[CH:31][C:32]([N:35]2[CH2:40][CH2:39][N:38]([C:14]3[N:13]([C:4]4[CH:5]=[C:6]([C:9]([F:12])([F:11])[F:10])[CH:7]=[CH:8][C:3]=4[O:2][CH3:1])[CH:22]([CH2:23][C:24]([O:26][CH3:27])=[O:25])[C:17]4[CH:18]=[N:19][CH:20]=[CH:21][C:16]=4[N:15]=3)[CH2:37][CH2:36]2)=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 752601-(4-Fluorophenyl)piperazineHCID 86620422HCID 86620422, compound

Product 1

HCID 59168066HCID 59168066, compound

Procedure

Starting from 565 mg (1.50 mmol) of the carbodiimide from Example 18A and 297 mg (1.65 mmol) of 4-fluorophenylpiperazine, general procedure [C] and purification by preparative HPLC result in 90 mg (10% of theory) of product.

Workup

  1. customresult in 90 mg (10% of theory) of product

Sources & evidence

ORD record
ord-16d58f72cba741f9b7741c89262082b8
Source dataset
uspto-grants-2012_06
Patent number
US08198282B2

Reaction notes

Loading…