反应详情

6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine hydrobromide (W2.001; 150 mg) was initially charged in water (5 ml) and admixed with diethylamine (814 μl) while stirring. Thereafter, the mixture was heated to reflux for 16 h and then further diethylamine (407 μl) was added. After refluxing for a further 12 h, the mixture was freed of the solvent, admixed with water and extracted three times with dichloromethane. The combined organic phases were dried over sodium sulfate and, after the desiccant had been filtered off, dried under reduced pressure. 67 mg of the title compound were obtained.

1. temperatureThereafter, the mixture was heated
2. temperatureto reflux for 16 h
3. temperatureAfter refluxing for a further 12 h
4. extractionextracted three times with dichloromethane
5. dry with materialThe combined organic phases were dried over sodium sulfate
6. filtrationafter the desiccant had been filtered off
7. customdried under reduced pressure