2,3,4-Trimethoxybenzoic acid → HCID 68276482, compound

HRID 2176795Notes

Reaction equation

HRID 2176795 reaction equation
[CH3:1][O:2][C:3]([N:5]1[C@@H:13]2[C@@H:8]([C@@:9]([OH:23])([C:14]#[C:15][C:16]3[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=3)[CH2:10][CH2:11][CH2:12]2)[CH2:7][CH2:6]1)=[O:4].[CH3:24][O:25][C:26]1[C:34]([O:35][CH3:36])=[C:33]([O:37][CH3:38])[CH:32]=[CH:31][C:27]=1[C:28](O)=[O:29]>>[CH3:1][O:2][C:3]([N:5]1[C@H:13]2[C@H:8]([C@@:9]([C:14]#[C:15][C:16]3[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=3)([O:23][C:28](=[O:29])[C:27]3[CH:31]=[CH:32][C:33]([O:37][CH3:38])=[C:34]([O:35][CH3:36])[C:26]=3[O:25][CH3:24])[CH2:10][CH2:11][CH2:12]2)[CH2:7][CH2:6]1)=[O:4]

Participants

3

Reactant 2

HCID 113082,3,4-Trimethoxybenzoic acidHCID 68276168(3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester

Product 1

HCID 68276482HCID 68276482, compound

Procedure

Synthesis in analogy to the General Method 1 starting from (3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester and 2,3,4-trimethoxy-benzoic acid to yield (3aR,4S,7aR)-4-m-tolylethynyl-4-(2,3,4-trimethoxy-benzoyloxy)-octahydro-indole-1-carboxylic acid methyl ester. MS [M+H]=296 (ester elimination ion); RT=8.527 min; HPLC Method I

Sources & evidence

ORD record
ord-fc7a1fade4a642079bbcae134fb8af0e
Source dataset
uspto-grants-2015_06
Patent number
US09067881B2

Reaction notes

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