2-Acetamidopyridine-4-carboxylic acid → HCID 60141331, compound

HRID 2176800Notes

Reaction equation

HRID 2176800 reaction equation
[CH3:1][O:2][C:3]([N:5]1[C@@H:13]2[C@@H:8]([C@@:9]([OH:23])([C:14]#[C:15][C:16]3[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=3)[CH2:10][CH2:11][CH2:12]2)[CH2:7][CH2:6]1)=[O:4].[C:24]([NH:27][C:28]1[CH:29]=[C:30]([CH:34]=[CH:35][N:36]=1)[C:31](O)=[O:32])(=[O:26])[CH3:25]>>[CH3:1][O:2][C:3]([N:5]1[C@H:13]2[C@H:8]([C@:9]([O:23][C:31]([C:30]3[CH:34]=[CH:35][N:36]=[C:28]([NH:27][C:24](=[O:26])[CH3:25])[CH:29]=3)=[O:32])([C:14]#[C:15][C:16]3[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=3)[CH2:10][CH2:11][CH2:12]2)[CH2:7][CH2:6]1)=[O:4]

Participants

3

Reactant 2

HCID 37744662-Acetamidopyridine-4-carboxylic acidHCID 68276168(3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester

Product 1

HCID 60141331HCID 60141331, compound

Procedure

Synthesis in analogy to the General Method 1 starting from (3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester and 2-acetylamino-isonicotinic acid to yield (3aR,4S,7aR)-4-(2-acetylamino-pyridine-4-carbonyloxy)-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester. MS [M+H] 476; RT=7.443 min HPLC Method I

Sources & evidence

ORD record
ord-14361df054864b88bb6d19445297ac53
Source dataset
uspto-grants-2015_06
Patent number
US09067881B2

Reaction notes

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