Cyanogen Bromide → HCID 58136895, compound

HRID 217696Notes

Reaction equation

HRID 217696 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[N:14]=[N:13][C:12]([NH:15][NH2:16])=[CH:11][C:10]=1[CH:17]1[CH2:19][CH2:18]1.[N:20]#[C:21]Br>>[Cl:8][C:9]1[C:10]([CH:17]2[CH2:19][CH2:18]2)=[CH:11][C:12]2[N:13]([C:21]([NH2:20])=[N:16][N:15]=2)[N:14]=1

Participants

3

Reactant 2

HCID 10476Cyanogen BromideHCID 86650807HCID 86650807, compound

Product 1

HCID 58136895HCID 58136895, compound

Procedure

(6-Chloro-5-cyclopropylpyridazin-3-yl)hydrazine trifluoroacetic acid salt (W3.012; 400 mg) was converted and worked up analogously to W2.008, except that, instead of 0.5, one further equivalent of cyanogen bromide solution was added. 260 mg of the title compound were obtained in sufficient purity.

Sources & evidence

ORD record
ord-d273ced451b04d0d86ab05ee44004f0d
Source dataset
uspto-grants-2012_06
Patent number
US08198272B2

Reaction notes

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