HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 2-Fluoro-6-(piperidin-1-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2,6-Difluorobenzonitrile | HCID 74695 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Fluoro-6-(piperidin-1-yl)benzonitrile | HCID 2780061 | 43.8% |
Reaction Steps
2,6-Difluorobenzonitrile (250 mg; 1.8 mmol) and piperidine (145 mg; 1.7 mmol) were mixed in DMF (5 mL) for 3 hours at RT. The solvent is removed under vacuum, and the resulting oil is dried under vacuum at 30° C. overnight to yield 152 milligrams of 2-fluoro-6-(piperidin-1-yl)benzonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09067897B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-fe8eeb21bb144b52a16cd7c0b7365d9a |
| Source note | uspto-grants-2015_06 |