Piperidine → 2-Fluoro-6-(piperidin-1-yl)benzonitrile

HRID 2176980Notes

Reaction equation

HRID 2176980 reaction equation
F[C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[C:4]#[N:5].[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>CN(C=O)C>[F:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:2]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[C:3]=1[C:4]#[N:5]

Participants

4

Reactant 2

HCID 8082PiperidineHCID 746952,6-Difluorobenzonitrile

Product 1

HCID 27800612-Fluoro-6-(piperidin-1-yl)benzonitrileYield 43.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2,6-Difluorobenzonitrile (250 mg; 1.8 mmol) and piperidine (145 mg; 1.7 mmol) were mixed in DMF (5 mL) for 3 hours at RT. The solvent is removed under vacuum, and the resulting oil is dried under vacuum at 30° C. overnight to yield 152 milligrams of 2-fluoro-6-(piperidin-1-yl)benzonitrile.

Workup

  1. customThe solvent is removed under vacuum
  2. customthe resulting oil is dried under vacuum at 30° C. overnight

Sources & evidence

ORD record
ord-fe8eeb21bb144b52a16cd7c0b7365d9a
Source dataset
uspto-grants-2015_06
Patent number
US09067897B2

Reaction notes

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