Thionyl Chloride → 4-Chlorobenzenepropanoyl chloride

HRID 2176982Notes

Reaction equation

HRID 2176982 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([OH:12])=O)=[CH:4][CH:3]=1.S(Cl)([Cl:15])=O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([Cl:15])=[O:12])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 123137beta-(p-Chlorophenyl)propionic acid

Product 1

HCID 122065164-Chlorobenzenepropanoyl chloride

Procedure

3-(4-Chlorophenyl)-propionic acid (3.83 g; 20.7 mmol) is dissolved in 50 ml thionyl chloride and stirred at room temperature overnight. The excess thionyl chloride is removed by rotary evaporation to give 3-(4-chlorophenyl)-propionyl chloride as a pale yellow oil, which is used without purification.

Workup

  1. customThe excess thionyl chloride is removed by rotary evaporation

Sources & evidence

ORD record
ord-2326e59681084aad94115a1e1a747815
Source dataset
uspto-grants-2015_06
Patent number
US09067897B2

Reaction notes

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